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Structural insights into the potency of SK channel positive modulators

Sci Rep. 2017; 7: 17178. Published online 2017 Dec 7. doi:  10.1038/s41598-017-16607-8 
Young-Woo Nam, Razan Orfali, Tingting Liu,  Kunqian Yu,  Meng Cui, Heike Wulff, and Miao Zhang
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A group from Chapman University School of Pharmacy have used a Bruker D8 Venture system with a MetalJet X-ray source to study a Small-conductance Ca2+-activated K+ (SK) channel. The interaction between four compounds acting as positive modulators and their binding pockets in the SK channel was investigated and a strong trend between interaction energy and the potency of the compounds was shown.


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